Representing 31 percent of all deaths, cardiovascular disease (CVD) is the No. 1 cause of death globally.1 Arterial wall retention of low-density lipoprotein cholesterol (LDL-C) and similar cholesterol-rich lipoproteins containing apolipoprotein B (ApoB) is a key initiating event in the development of CVD.2 Furthermore, a plethora of evidence shows that elevated low-density lipoprotein cholesterol (LDL-C) level is a major modifiable risk factor for CVD.3 This certainly makes LDL-C a major target for CVD risk reduction.4,5 Probiotics for Cholesterol Reduction There has been significant interest in the use of dietary supplements to help lower LDL-C levels. This interest is likely due to the fact that some patients have milder forms of hypercholesterolemia or as an alternative to statins in patients who may have experienced or are worried about side effects.6 Heretofore, the most studied nutraceuticals include monacolin K (a structural analogue of lovastatin) found in red yeast rice, plant sterols and stanols, and beta-glucans.7,8 Additionally, the gut microbiota has also been implicated in the regulation of cholesterol homeostasis,9,10 which led to the study of probiotics for their effect on lipid metabolism and cholesterol-lowering effects. Among these, a combination of three Lactobacillus plantarum strains, collectively called Floradapt Cardio, has shown particular promise. [...]
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